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 * Advance d** **Topics in Genetics and Development Project **

The goal of this project is to have you delve deeper into areas of genetics and development that we will be covering in class. By looking into these advanced topics, many of which are subjects of very active research, you will develop a better understanding of the basics. When you create your Power Points and Wiki pages you will need to find the balance between the basic and the advanced material. I can’t imagine that you can discuss genetic control, for example, without presenting transcription, or, epigenetics without presenting chromosome and DNA structure. However, you do not need to go into great detail about these. Your job is not to teach about the basics. Your job is to teach about the advanced concepts and use the basics as needed to help the rest of us understand. You will work in teams of three unless I assign teams otherwise. You assemble the teams, I will assign the topics.




 * Topics: **
 * The cell cycle: stages, mitosis, control, CDK, telomeres
 * Cancer: characteristics, genetics, mutations, repair mechanisms
 * Control of gene expression: Transcription factors, epigenetics, transcript processing
 * Stem cells, cell determination and cell differentiation, cell signaling
 * Creating body plans: master genes (e.g. Hox, Bimp, Sonic Hedgehog etc.), early embryo development, cell signaling
 * Creating variation: Meiosis, spermatogenesis, oogenesis, fertilization, genomic imprinting
 * Modification of genes and proteins: transcript processing, protein folding, RNAi, gene repair
 * Creating bodies: implantation, invagination, gastrulation, neurulation, cephalization, organ formation


 * Tasks: **
 * Self evaluation carefully describing your contributions to the project
 * Power point slides with notes
 * <span style="font-family: 'Times New Roman','serif';">Presentation of Power Point in class (30 minutes)
 * <span style="font-family: 'Times New Roman','serif';">Wiki page on same topic as power point including:
 * <span style="font-family: 'Times New Roman','serif';">Information that is in the Power Point
 * <span style="font-family: 'Times New Roman','serif';">Power point uploaded.
 * <span style="font-family: 'Times New Roman','serif';">Use of (or creation of) video
 * <span style="font-family: 'Times New Roman','serif';">Annotated links
 * <span style="font-family: 'Times New Roman','serif';">10 Multiple choice review questions
 * <span style="font-family: 'Times New Roman','serif';">1 AP style essay (with AP style answer key supplied to me.)


 * <span style="font-family: 'Times New Roman','serif';">Textbook chapters: **
 * <span style="font-family: 'Times New Roman','serif';">Chapters 12-17 cover the basics of the cell cycle, heredity and molecular genetics.
 * <span style="font-family: 'Times New Roman','serif';">Chapters 18-21 and 46-47 cover more advanced topics in genetics, genetic control and development

<span style="font-family: 'Times New Roman',Times,serif;">**Sources** to get you started. You should all check out all of these links:
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.nature.com/scitable/topic/genetics-5
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.nature.com/scitable/topic/cell-biology-13906536 The two sites above contain many articles that related to the above topics. These are written by researchers in the field. Be sure to check these out and try to use at least one article.
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.eurostemcell.org/films/a-stem-cell-story/English A great video about stem cells
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://outreach.mcb.harvard.edu/materials.htm A set of animations (flash) that illustrate the genetics of stem cells and cell differentiation
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.pbs.org/wgbh/nova/body/rnai.html A video about RNAi
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.dnaftb.org/
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.dnai.org/a/index.html Two primers on molecular genetics
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.insidecancer.org/ The best teaching source about cancer. Plan to spend awhile exploring this site
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.visembryo.com/baby/ Examine all the stages of embryo development
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.cellsalive.com/ Primers on meiosis, the cell cycle and cell division
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.pbs.org/wgbh/nova/teachers/body/epigenetics.html A short video about epigenetics
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://www.youtube.com/watch?v=LFG-aLidT8s Video on evo-devo
 * <span style="font-family: 'Times New Roman',Times,serif;">@http://learn.genetics.utah.edu/ Primers on all aspects of genetics (including the basics as well as stem cells, and epigenetics).

<span style="font-family: 'Times New Roman','serif';">Your project will be assessed on: <span style="font-family: 'Times New Roman','serif';">Please see the rubric for complete details. <span style="font-family: 'Times New Roman','serif';">This project is worth 200 points.
 * <span style="font-family: 'Times New Roman','serif';">Grading: **
 * <span style="font-family: 'Times New Roman','serif';">Thoroughness and accuracy of the science presented
 * <span style="font-family: 'Times New Roman','serif';">Creative quality and effectiveness of the materials you use/create
 * <span style="font-family: 'Times New Roman','serif';">Use of examples to explain concepts
 * <span style="font-family: 'Times New Roman','serif';">You will be graded on your contributions to the project

<span style="font-family: 'Times New Roman','serif';"> __for completion of wiki page and Power Point__
 * <span style="font-family: 'Times New Roman','serif';">Due Dates: **

for class presentations